Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice
Abstract Elucidating the underlying molecular mechanisms regulating fear and extinction learning may offer insights that can lead to novel treatments…
FAAH
Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation
Abstract Modulating the activity of the endocannabinoid system influences various gastrointestinal physiological and pathophysiological processes, and cannabinoid receptors as well…
Poorer frontolimbic white matter integrity is associated with chronic cannabis use, FAAH genotype, and increased depressive and apathy symptoms in adolescents and young adults
Abstract Background: The heaviest period of cannabis use coincides with ongoing white matter (WM) maturation. Further, cannabis-related changes may be…
A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice
Abstract Objective: The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid (CB) receptor, whose role in the gastrointestinal (GI)…
The Endocannabinoid System as Pharmacological Target Derived from Its CNS Role in Energy Homeostasis and Reward. Applications in Eating Disorders and Addiction
Abstract The endocannabinoid system (ECS) has been implicated in many physiological functions, including the regulation of appetite, food intake and…