FAAH and MAGL inhibition: Evolving approaches to treating substance use disorders
Abstract Substance use disorder (SUD) remains a critical public health issue characterized by high rates of relapse and limited effective…
FAAH
Dysregulation of the endocannabinoid system – a key factor in the progression of multiple sclerosis?
Abstract The endocannabinoid system has been implicated in the pathophysiology of multiple sclerosis (MS), yet its role across different disease…
Three-day delta-9-tetrahydrocannabinol (THC) exposure eliminates long-term depression in ventral tegmental area of young, but not adult mice
Abstract Ventral tegmental area (VTA) dopamine signaling plays a key role in reward learning and drug dependence. VTA dopamine cell…
FAAH Modulators from Natural Sources: A Collection of New Potential Drugs
Abstract The endocannabinoid system (ECS) plays a crucial role in maintaining homeostasis by regulating immune response, energy metabolism, cognitive functions,…
Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice
Abstract Background: Some evidence suggests that cannabidiol (CBD) has potential to help alleviate HIV symptoms due to its antioxidant and…
The endocannabinoid system as a putative target for the development of novel drugs for the treatment of psychiatric illnesses
Abstract Cannabis is well established to impact affective states, emotion and perceptual processing, primarily through its interactions with the endocannabinoid…
Endocannabinoids regulate cocaine-associated memory through brain AEA–CB1R signalling activation
Abstract Objective: Contextual drug-associated memory precipitates craving and relapse in substance users, and the risk of relapse is a major…
Sex and stressor modality influence acute stress-induced dynamic changes in corticolimbic endocannabinoid levels in adult Sprague Dawley rats
Abstract Research over the past few decades has established a role for the endocannabinoid system in contributing to the neural…
Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis
Abstract The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal barrier function and immune regulation are key determinants…
Clinical Data on Canabinoids: Translational Research in the Treatment of Autism Spectrum Disorders
Abstract Translational research made with Cannabis sativa L. and its biocompounds provides data for some targeted diseases, as also symptoms…