Enzyme mechanisms

March 30, 2022

Geotemporospatial and causal inferential epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003–2017: part 3 – spatiotemporal, multivariable and causal inferential pathfinding and exploratory analyses of prostate and ovarian cancers

Abstract Background : The epidemiology of cannabinoid-related cancerogenesis has not been studied with cutting edge epidemiological techniques. Building on earlier…

January 19, 2022

Geotemporospatial and causal inference epidemiological analysis of US survey and overview of cannabis, cannabidiol and cannabinoid genotoxicity in relation to congenital anomalies 2001–2015

Abstract Background: Cannabinoids including cannabidiol have recognized genotoxic activities but their significance has not been studied broadly epidemiologically across the…

July 11, 2021

Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence

Abstract Background: Ethnic differences in testicular cancer rates (TCRs) are recognized internationally. Cannabis is a known risk factor for testicular…

May 10, 2021

In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach

Abstract The liver is among the most frequently targeted organs by noxious chemicals of diverse nature. Liver toxicity testing using…

November 30, 2020

Contemporary epidemiology of rising atrial septal defect trends across USA 1991–2016: a combined ecological geospatiotemporal and causal inferential study

Abstract Background: Cardiovascular anomalies are the largest group of congenital anomalies and the major cause of death in young children,…

August 11, 2018

Anti-stress neuropharmacological mechanisms and targets for addiction treatment: A translational framework

Abstract Stress-related substance use is a major challenge for treating substance use disorders. This selective review focuses on emerging pharmacotherapies…

March 20, 2012

Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase*

Abstract Background: Rbx1/ROC1 is an E3 ligase adaptor protein that functions with the E2 enzyme CDC34. Results: NMR and biochemical…