The Anticonvulsant Effects of Different Cannabis Extracts in a Zebrafish Model of Epilepsy
Abstract Epilepsy is a widespread neurological disorder that remains a critical global public health challenge. While numerous antiepileptic drugs (AEDs)…
entourage effect
Sex Differences in the Anxiolytic Properties of Common Cannabis Terpenes, Linalool and β-Myrcene, in Mice
Abstract Volatile organic compounds, colloquially referred to as “terpenes”, have been proposed to impact the therapeutic qualities that are traditionally…
The Entourage Effect in Cannabis Medicinal Products: A Comprehensive Review
Abstract This study explores the complementary or synergistic effects of medicinal cannabis constituents, particularly terpenes, concerning their therapeutic potential, known…
In Vitro and In Vivo Anti-Inflammatory and Antidepressant-like Effects of Cannabis sativa L. Extracts
Abstract Cannabis sativa L. has been widely used by humans for centuries for various purposes, such as industrial, ceremonial, medicinal,…
Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t
Abstract The ‘entourage effect’ term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of…
Effects of combined cannabidiol (CBD) and hops (Humulus lupulus) terpene extract treatment on RAW 264.7 macrophage viability and inflammatory markers
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s13659-023-00382-3. Article type: Research Article Keywords: CBD, Terpenes, Cannabinoids,…
Systematic combinations of major cannabinoid and terpene contents in Cannabis flower and patient outcomes: a proof-of-concept assessment of the Vigil Index of Cannabis Chemovars
Abstract Background: Little is known about the frequency with which different combinations of phytochemicals (chemovars) arise in Cannabis flower or…
Secondary Terpenes in Cannabis sativa L.: Synthesis and Synergy
Abstract Cannabis is a complex biosynthetic plant, with a long history of medicinal use. While cannabinoids have received the majority…
The Endocannabinoid Analgesic Entourage Effect: Investigations in Cultured DRG Neurons
Abstract Background: The endocannabinoid 2-Arachidonyl glycerol (2-AG) exerts dose-related anti-nociceptive effects, which are potentiated by the related but inactive 2-palmitoyl…
Optimal Treatment with Cannabis Extracts Formulations Is Gained via Knowledge of Their Terpene Content and via Enrichment with Specifically Selected Monoterpenes and Monoterpenoids
Abstract Differences between therapeutic effects of medical cannabis inflorescences and those of their extracts are generally attributed to the differences…