Marijuana, the Endocannabinoid System and the Female Reproductive System
Abstract Marijuana use among women is highly prevalent, but the societal conversation on marijuana rarely focuses on how marijuana affects…
endocannabinoid system
Cannabinoid receptor type-1: breaking the dogmas
Abstract The endocannabinoid system (ECS) is abundantly expressed in the brain. This system regulates a plethora of physiological functions and…
Modulation of cellular redox homeostasis by the endocannabinoid system
Abstract The endocannabinoid system (ECS) and reactive oxygen species (ROS) constitute two key cellular signalling systems that participate in the…
The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory
Abstract The endocannabinoid system (ECS) is a group of neuromodulatory lipids and their receptors, which are widely distributed in mammalian…
Endocannabinoids in the Gut
Abstract Cannabis has been used medicinally for centuries to treat a variety of disorders, including those associated with the gastrointestinal…
Hypothalamic control of brown adipose tissue thermogenesis
Abstract It has long been known, in large part from animal studies, that the control of brown adipose tissue (BAT)…
Cannabinoid Ligands and Alcohol Addiction: A Promising Therapeutic Tool or a Humbug?
Abstract The vast therapeutic potential of cannabinoids of both synthetic and plant-derived origins currently makes these compounds the focus of…
4′-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation
Abstract Background and purpose: 4′-O-methylhonokiol (MH) is a natural product showing anti-inflammatory, anti-osteoclastogenic, and neuroprotective effects. MH was reported to…
Role of the Endogenous Cannabinoid System in Nicotine Addiction: Novel Insights
Abstract Several lines of evidence have shown that the endogenous cannabinoids are implicated in several neuropsychiatric diseases. Notably, preclinical and…
Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: A randomised, double-blind, placebo-controlled study in cannabis users
Abstract Acute administration of the primary psychoactive constituent of cannabis, Δ-9-tetrahydrocannabinol (THC), impairs human facial affect recognition, implicating the endocannabinoid…