Dysregulation of the endocannabinoid system – a key factor in the progression of multiple sclerosis?
Abstract The endocannabinoid system has been implicated in the pathophysiology of multiple sclerosis (MS), yet its role across different disease…
ECS tone
The endocannabinoid system and ophthalmic pathologies: a review of molecular mechanisms and its implications for clinical practice
Abstract Within the last decade the role of the endocannabinoid system (ECS) has been a significant part of ophthalmic research,…
Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review
Abstract Since the discovery of the endocannabinoid system and due to the empirical evidence of the therapeutic effects on several…
Placental Cannabinoid Receptor Expression in Preterm Birth
Abstract Background: The cannabinoid receptor (CBR) plays a significant role in oogenesis, pregnancy, and childbirth. It might also play a…
Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review
Abstract Cannabidiol (CBD) is a terpenoid naturally found in plants. The purified compound is used in the treatment of mental…
The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg
Abstract Childhood absence epilepsy (CAE) is a non-convulsive seizure disorder primarily in children characterized by absence seizures. Absence seizures consist…
Prolonged efavirenz exposure reduces peripheral oxytocin and vasopressin comparable to known drugs of addiction in male Sprague Dawley rats
Abstract Introduction: Several drugs of abuse (DOA) are capable of modulating neurohypophysial hormones, such as oxytocin (OT) and vasopressin (VP),…
Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils
Abstract The endocannabinoid system (ECS) consists of endogenous cannabinoids, their receptors, and metabolic enzymes that play a critical homeostatic role…
Targeting the endocannabinoid system for management of HIV-associated neuropathic pain: A systematic review
Abstract Human immunodeficiency virus (HIV) infection and antiretroviral therapy can independently induce HIV-associated neuropathic pain (HIV-NP). There is a dearth…
CannabinEYEds: The Endocannabinoid System as a Regulator of the Ocular Surface Nociception, Inflammatory Response, Neovascularization and Wound Healing
Abstract The endocannabinoid system (ECS) is a complex regulatory system, highly conserved among vertebrates. It has been widely described in…