Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides
Abstract Despite the pivotal importance of the ubiquitin–proteasome pathway to the survival of Plasmodium, the parasite causing malaria, there is…
E3 ubiquitin ligase
The disordered PCI‐binding human proteins CSNAP and DSS1 have diverged in structure and function
Abstract Intrinsically disordered proteins (IDPs) regularly constitute components of larger protein assemblies contributing to architectural stability. Two small, highly acidic…
Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs
Abstract Ubiquitin is a small protein at the heart of many cellular processes, and several different protein domains are known…
Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms
Abstract WWP2 is an E3 ubiquitin ligase that differentially regulates the contextual tumour suppressor/progressor TGFβ signalling pathway by alternate isoform…
1H, 13C, and 15N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCH
Abstract ITCH (aka Atrophin-1-interacting protein 4) is a prominent member of the NEDD4 HECT (Homologous to E6AP C-Terminus) E3 ubiquitin…
The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL*
Abstract Background: The E3 ligase FANCL monoubiquitinates FANCD2 in a critical step in the repair of DNA interstrand crosslinks. Results:…
Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase*
Abstract Background: Rbx1/ROC1 is an E3 ligase adaptor protein that functions with the E2 enzyme CDC34. Results: NMR and biochemical…
Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12*
Abstract Schizosaccharomyces pombe Rpn10 (SpRpn10) is a proteasomal ubiquitin (Ub) receptor located within the 19 S regulatory particle where it…