Abstract Background: The identification of critical states during disease progression is essential yet challenging for preventing disease deterioration and developing…
Abstract Complex disease progression typically involves sudden and non-linear transitions accompanied by devastating effects. Uncovering such critical states or pre-disease…
Abstract Background: There exists a critical transition or tipping point during the complex biological process. Such critical transition is usually…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12859-024-05667-z. Article type: Research Article Keywords: Dynamic network biomarker…
Abstract Background: There are sudden deterioration phenomena during the progression of many complex diseases, including most cancers; that is, the…
Abstract Background: Developing effective strategies for signaling the pre-disease state of complex diseases, a state with high susceptibility before the…