A pan-cancer landscape of centromere proteins in tumorigenesis and anticancer drug sensitivity
Abstract CENPs activated the cell cycle signaling pathway and inhibited the RAS/MAPK, hormone ER and hormone AR pathways. CENP family…
Drug sensitivity
Pan-cancer analysis of the prognostic and immunological role of SNX29: a potential target for survival and immunotherapy
Abstract Background: There is growing evidence that the SNX family is critical for clinical prognosis, immune infiltration and drug sensitivity…
Systematic analysis identifies XRCC4 as a potential immunological and prognostic biomarker associated with pan-cancer
Abstract Background: XRCC4 is a NHEJ factor identified recently that plays a vital role in repairing DNA double-stranded breaks. Studies…
Pan-cancer analyses reveal IGSF10 as an immunological and prognostic biomarker
Abstract Background: IGSF10 is a member of the immunoglobulin superfamily. Over the previous decade, growing proof has validated definitive correlations…
Pan‐cancer analyses reveal molecular and clinical characteristics of cuproptosis regulators
Abstract Imbalance in copper homeostasis can be lethal. A recent study found that excess copper induces cell death in a…
LPCAT1 acts as an independent prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma
Abstract Background: Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is overexpressed in multiple human tumors. However, the role of LPCAT1 in hepatocellular carcinoma…
REV1: A novel biomarker and potential therapeutic target for various cancers
Abstract Background: REV1 is a member of the translesion synthesis DNA polymerase Y family. It is an essential player in…
Integrative pan-cancer analysis and clinical characterization of the N7-methylguanosine (m7G) RNA modification regulators in human cancers
Abstract Background: RNA modification is one of the epigenetic mechanisms that regulates post-transcriptional gene expression, and abnormal RNA modifications have…
Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis
Abstract Ferredoxin 1 (FDX1) functions by transferring electrons from NADPH to mitochondrial cytochrome P450 via the ferredoxin reductase and is…
Pan-cancer analysis of CREB3L1 as biomarker in the prediction of prognosis and immunotherapeutic efficacy
Abstract Background: CAMP response element binding protein 3-like 1 (CREB3L1) has been indicated as a critical biomarker and can modulate…