Validation of transcriptome signature reversion for drug repurposing in oncology
Abstract Transcriptome signature reversion (TSR) has been extensively proposed and used to discover new indications for existing drugs (i.e. drug…
drug repositioning
A network medicine approach for identifying diagnostic and prognostic biomarkers and exploring drug repurposing in human cancer
Keywords: Systems medicine, Drug repositioning, Network oncology, Gene prioritization, Machine learning, Pan-cancer diagnosis and prognosis Authors: Le Zhang, Shiwei Fan,…
Overcoming Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: Repurposed Drugs Can Improve the Protocol
Abstract Glucocorticoids (GCs) are a central component of multi-drug treatment protocols against T and B acute lymphoblastic leukemia (ALL), which…