UGT2B7-mediated drug–drug interaction between cannabinoids and hydromorphone
Abstract Hydromorphone is a highly potent opioid used to treat severe chronic pain. It is metabolized primarily by UDP-glucuronosyltransferase (UGT)2B7…
drug–drug interactions
Inhibition of Tacrolimus Metabolism by Cannabidiol and Its Metabolites In Vitro
Abstract Drug interactions are major causes of interindividual variability in tacrolimus exposure and effect. Tacrolimus, a widely used drug in…
Utilization of Cannabidiol in Post-Organ-Transplant Care
Abstract Cannabidiol (CBD) is one of the major phytochemical constituents of cannabis, Cannabis sativa, widely recognized for its therapeutic potential.…
Drug–Cannabinoid Interactions in Selected Therapeutics for Symptoms Associated with Epilepsy, Autism Spectrum Disorder, Cancer, Multiple Sclerosis, and Pain
Abstract Clinical practice entails a translation of research that assists in the use of scientific data and therapeutic evidence for…
CBD and THC in Special Populations: Pharmacokinetics and Drug–Drug Interactions
Abstract Cannabinoid use has surged in the past decade, with a growing interest in expanding cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC)…
Cannabinoid-Induced Inhibition of Morphine Glucuronidation and the Potential for In Vivo Drug–Drug Interactions
Abstract Opioids are commonly prescribed for the treatment of chronic pain. Approximately 50% of adults who are prescribed opioids for…
Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t
Abstract The ‘entourage effect’ term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of…
Drug–Drug Interactions of Cannabidiol with Standard-of-Care Chemotherapeutics
Abstract Cannabidiol (CBD) is an easily accessible and affordable Marijuana (Cannabis sativa L.) plant derivative with an extensive history of…
Potential Adverse Drug Events with Tetrahydrocannabinol (THC) Due to Drug–Drug Interactions
Abstract Tetrahydrocannabinol (THC) is the primary psychoactive ingredient in cannabis. While the safety of THC and cannabis has been extrapolated…
Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use
Abstract Cannabidiol (CBD) is ubiquitous in state-based medical cannabis programs and consumer products for complementary health or recreational use. CBD…