Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria
Abstract The cannabinoid cannabidiol (CBD) is characterised in this study as a helper compound against resistant bacteria. CBD potentiates the…
Drug discovery
A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol
Abstract (-)-Trans-Δ9-tetrahydrocannabinol (Δ9-THC) is the main compound responsible for the intoxicant activity of Cannabis sativa L. The length of the…
Molecular Docking: Shifting Paradigms in Drug Discovery
Abstract Molecular docking is an established in silico structure-based method widely used in drug discovery. Docking enables the identification of…
Intracellular Peptides in Cell Biology and Pharmacology
Abstract Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed…
Animal models of PTSD: a challenge to be met
Abstract Recent years have seen increased interest in psychopathologies related to trauma exposure. Specifically, there has been a growing awareness…
A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research
Abstract The origins of the major classes of current anti-emetics are examined. Serendipity is a recurrent theme in discovery of…
Synthesis and Cytotoxic Activity of Novel Tetrahydrocurcumin Derivatives Bearing Pyrazole Moiety
Abstract Abstract: Tetrahydrocurcumin (THC) is a major metabolite of curcumin and plays an important role in curcumin-induced biological effects. THC…
Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid
Abstract Introduction: In recent research, orally administered cannabidiol (CBD) showed a relatively high incidence of somnolence in a pediatric population.…
Discovery and resupply of pharmacologically active plant-derived natural products: A review
Abstract Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent…
Two dimensional NMR spectroscopic approaches for exploring plant metabolome: A review
Keywords: Nuclear magnetic resonance (NMR), Phytomedicines, Drug discovery, 2D NMR, Metabolomics, Chemometrics Authors: Engy A. Mahrous, Mohamed A. Farag License:…