Drug discovery and development

May 15, 2024

Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region

Abstract Safe and effective pain management is a critical healthcare and societal need. The potential for acute liver injury from…

November 9, 2023

A novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation

Abstract Multiple tumors are synergistically promoted by c-Met and TRK, and blocking their cross-signalling pathway may give better effects. In…

January 19, 2021

The antimicrobial potential of cannabidiol

Abstract Antimicrobial resistance threatens the viability of modern medicine, which is largely dependent on the successful prevention and treatment of…