Glaucoma Clinical Research: Trends in Treatment Strategies and Drug Development
Abstract Purpose: To investigate the trends and progresses in glaucoma research by searching two major clinical trial registries; clinicaltrials.gov, and…
drug development
Deep generative neural network for accurate drug response imputation
Abstract Drug response differs substantially in cancer patients due to inter- and intra-tumor heterogeneity. Particularly, transcriptome context, especially tumor microenvironment,…
A phase 1b randomised, placebo-controlled trial of nabiximols cannabinoid oromucosal spray with temozolomide in patients with recurrent glioblastoma
Abstract Background: Preclinical data suggest some cannabinoids may exert antitumour effects against glioblastoma (GBM). Safety and preliminary efficacy of nabiximols…
Induction of posterior vitreous detachment (PVD) by non-enzymatic reagents targeting vitreous collagen liquefaction as well as vitreoretinal adhesion
Abstract Induction of posterior vitreous detachment (PVD) by pharmacologic vitreolysis has been largely attempted through the use of enzymatic reagents.…
Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain
Abstract Chronic pain is a common detrimental condition that affects around 20% of the world population. The current drugs to…
Collision cross sections obtained with ion mobility mass spectrometry as new descriptor to predict blood-brain barrier permeation by drugs
Abstract Evaluating the ability of a drug to permeate the blood-brain barrier is not a trivial task due to the…
Allosteric Modulation of Cannabinoid Receptor 1—Current Challenges and Future Opportunities
Abstract The cannabinoid receptor type 1 (CB1R), a G protein-coupled receptor (GPCR), plays an essential role in the control of…
Cannabidiol directly targets mitochondria and disturbs calcium homeostasis in acute lymphoblastic leukemia
Abstract Anticancer properties of non-psychoactive cannabinoid cannabidiol (CBD) have been demonstrated on tumors of different histogenesis. Different molecular targets for…
Contrasting Roles of Cannabidiol as an Insecticide and Rescuing Agent for Ethanol–induced Death in the Tobacco Hornworm Manduca sexta
Abstract Cannabis sativa, also known as marijuana or hemp, produces a non-psychoactive compound cannabidiol (CBD). To investigate the defensive role…
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
Abstract The MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including…