Cannabinoid Receptor 2 (CB2) in Macrophages: A Promising Clinical Target for Immune Disorders
Abstract Macrophages are essential for immune homeostasis, playing crucial roles in immune responses from initiation to resolution. They trigger acute…
drug development
Acute toxicological evaluation of bone-targeted parathyroid hormone-related peptide (PTHrP) antagonist to inhibit breast cancer metastases to bone
Abstract The present study evaluates the in vivo acute toxicological profile and drug distribution of a novel bone-targeted parathyroid hormone-related…
High hopes, hard realities: cannabidiol shows no acute effects in youth with alcohol use disorder
Keywords: Drug development, Translational research Authors: L. Cinnamon Bidwell Affiliations: https://ror.org/02ttsq026grid.266190.a0000 0000 9621 4564University of Colorado Boulder, Boulder, CO USA…
The neural and psychophysiological effects of cannabidiol in youth with alcohol use disorder: A randomized controlled clinical trial
Abstract Novel treatment evaluation for youth with alcohol use disorder (AUD) is needed. Cannabidiol (CBD), a constituent of the Cannabis…
The efficacy of elevating anandamide via inhibition of fatty acid amide hydrolase (FAAH) combined with internet-delivered cognitive behavioral therapy in the treatment of post-traumatic stress disorder: a randomized, placebo-controlled clinical trial
Abstract Post-traumatic stress disorder (PTSD) is a severe mental health disorder with limited treatment options. Gold standard treatment includes cognitive…
Targeting c-MET Alterations in Cancer: A Review of Genetic Drivers and Therapeutic Implications
Abstract This review focuses on the role of the MET proto-oncogene in cancer and how alterations in this gene contribute…
Research and Clinical Practice Involving the Use of Cannabis Products, with Emphasis on Cannabidiol: A Narrative Review
Abstract Background: Emerging evidence supports cannabidiol (CBD) as a promising therapeutic compound for various health conditions, despite its approval as…
A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats
Abstract Medicinal cannabis is being used worldwide and there is increasing use of novel cannabis products in the community. Cannabis…
JWH-182: a safe and effective synthetic cannabinoid for chemotherapy-induced neuropathic pain in preclinical models
Abstract Chemotherapy-induced neuropathic pain (CINP), a condition with unmet treatment needs, affects over half of cancer patients treated with chemotherapeutics.…
Alzheimer’s disease drug development pipeline: 2024
Keywords: Alzheimer’s disease, amyloid, biomarkers, clinical trials, Common Alzheimer’s Disease Research Ontology (CADRO), drug development, inflammation, pharmaceutical companies, repurposed drugs,…