Cannabinoid Receptor 2 (CB2) in Macrophages: A Promising Clinical Target for Immune Disorders
Abstract Macrophages are essential for immune homeostasis, playing crucial roles in immune responses from initiation to resolution. They trigger acute…
drug development
For those with schizophrenia, does cannabidiol make cannabis use safer?
Keywords: Schizophrenia, Drug development Authors: Anya K. Bershad ⚬ Affiliations: https://ror.org/046rm7j60grid.19006.3e0000 0000 9632 6718Department of Psychiatry and Biobehavioral Sciences, Jane…
High hopes, hard realities: cannabidiol shows no acute effects in youth with alcohol use disorder
Keywords: Drug development, Translational research Authors: L. Cinnamon Bidwell Affiliations: https://ror.org/02ttsq026grid.266190.a0000 0000 9621 4564University of Colorado Boulder, Boulder, CO USA…
The neural and psychophysiological effects of cannabidiol in youth with alcohol use disorder: A randomized controlled clinical trial
Abstract Novel treatment evaluation for youth with alcohol use disorder (AUD) is needed. Cannabidiol (CBD), a constituent of the Cannabis…
The efficacy of elevating anandamide via inhibition of fatty acid amide hydrolase (FAAH) combined with internet-delivered cognitive behavioral therapy in the treatment of post-traumatic stress disorder: a randomized, placebo-controlled clinical trial
Abstract Post-traumatic stress disorder (PTSD) is a severe mental health disorder with limited treatment options. Gold standard treatment includes cognitive…
Research and Clinical Practice Involving the Use of Cannabis Products, with Emphasis on Cannabidiol: A Narrative Review
Abstract Background: Emerging evidence supports cannabidiol (CBD) as a promising therapeutic compound for various health conditions, despite its approval as…
A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats
Abstract Medicinal cannabis is being used worldwide and there is increasing use of novel cannabis products in the community. Cannabis…
JWH-182: a safe and effective synthetic cannabinoid for chemotherapy-induced neuropathic pain in preclinical models
Abstract Chemotherapy-induced neuropathic pain (CINP), a condition with unmet treatment needs, affects over half of cancer patients treated with chemotherapeutics.…
Alzheimer’s disease drug development pipeline: 2024
Keywords: Alzheimer’s disease, amyloid, biomarkers, clinical trials, Common Alzheimer’s Disease Research Ontology (CADRO), drug development, inflammation, pharmaceutical companies, repurposed drugs,…
Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials
Abstract Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate its treatment. AEF0117, the first of…