Distinctive chromosomal, mutational and transcriptional profiling in colon versus rectal cancers
Abstract Background: Colorectal cancer (CRC) encompasses tumors arising in the colon (CC) and rectum (RC), often treated as a single…
driver genes
DriverSubNet: A Novel Algorithm for Identifying Cancer Driver Genes by Subnetwork Enrichment Analysis
Abstract Identification of driver genes from mass non-functional passenger genes in cancers is still a critical challenge. Here, an effective…
Integrating omics data and protein interaction networks to prioritize driver genes in cancer
Abstract Although numerous approaches have been proposed to discern driver from passenger, identification of driver genes remains a critical challenge…
LNDriver: identifying driver genes by integrating mutation and expression data based on gene-gene interaction network
Abstract Background: Cancer is a complex disease which is characterized by the accumulation of genetic alterations during the patient’s lifetime.…