Cannabidiol in epilepsy: The indications and beyond
Abstract Epilepsy, although common, remains difficult to treat with as much as 30% of patients having treatment-resistant conditions. Lennox-Gastaut syndrome…
Dravet syndrome
Cannabidiol Treatment for Refractory Epilepsies in Pediatrics
Abstract Cannabis extracts in oil are becoming increasingly available, and, during the last years, there has been growing public and…
Clinical implications of trials investigating drug‐drug interactions between cannabidiol and enzyme inducers or inhibitors or common antiseizure drugs
Abstract Highly purified cannabidiol (CBD) has demonstrated efficacy with an acceptable safety profile in patients with Lennox‐Gastaut syndrome or Dravet…
Slow Titration of Cannabidiol Add-On in Drug-Resistant Epilepsies Can Improve Safety With Maintained Efficacy in an Open-Label Study
Abstract Objective: To assess adverse events (AEs) and efficacy of add-on cannabidiol (CBD) with a slower titration protocol in pediatric…
A Survey on Cannabinoid Treatment of Pediatric Epilepsy Among Neuropediatricians in Scandinavia and Germany
Abstract Objectives: There is an increasing interest in cannabinoid-based products for the treatment of refractory pediatric epilepsy. However, a licensed…
Cannabidiol efficacy independent of clobazam: Meta‐analysis of four randomized controlled trials
Abstract Objective: The efficacy of cannabidiol (CBD) with and without concomitant clobazam (CLB) was evaluated in stratified analyses of four…
Medical Cannabis for Intractable Epilepsy in Childhood: A Review
Abstract In recent years, cannabis has been gaining increasing interest in both the medical research and clinical fields, with regard…
Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions
Abstract Objective: Cannabidiol (CBD) has been approved by the US Food and Drug Administration (FDA) to treat intractable childhood epilepsies,…
Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome
Abstract Cannabidiol (CBD) reduces seizures in childhood epilepsy syndromes including Dravet syndrome (DS). A formulation of CBD has obtained orphan…