Meiotic Genes and DNA Double Strand Break Repair in Cancer
Abstract Tumor cells show widespread genetic alterations that change the expression of genes driving tumor progression, including genes that maintain…
DNA repair
DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease
Abstract Repair of covalent DNA-protein crosslinks (DPCs) by DNA-dependent proteases has emerged as an essential genome maintenance mechanism required for…
Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies
Abstract The mechanism of neuronal dysfunction via tau aggregation in tauopathy patients is controversial. In Alzheimer’s disease (AD), we previously…
Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1
Abstract XRCC1 accelerates repair of DNA single-strand breaks by acting as a scaffold protein for the recruitment of Polβ, LigIIIα,…
The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL*
Abstract Background: The E3 ligase FANCL monoubiquitinates FANCD2 in a critical step in the repair of DNA interstrand crosslinks. Results:…