Distinctive chromosomal, mutational and transcriptional profiling in colon versus rectal cancers
Abstract Background: Colorectal cancer (CRC) encompasses tumors arising in the colon (CC) and rectum (RC), often treated as a single…
DNA copy number alterations
CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications
Abstract Somatic copy number alterations (CNAs) are a hallmark of cancer, but their role in tumorigenesis and clinical relevance remain…
Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types
Abstract Background: Inhibition of the PD-L1/PD-1 immune checkpoint axis represents one of the most promising approaches of immunotherapy for various…
Integrative epigenetic and genetic pan-cancer somatic alteration portraits
Abstract Genetic and epigenetic alterations are required for carcinogenesis and the mutation burden across tumor types has been investigated. Here,…