Diseases of the nervous system

December 28, 2024

Uncovering metabolic dysregulation in schizophrenia and cannabis use disorder through untargeted plasma lipidomics

Abstract Cannabis use disorder affects up to 42% of individuals with schizophrenia, correlating with earlier onset, increased positive symptoms, and…

October 16, 2024

Cannabis use disorder increases risk of large-artery atherosclerotic stroke and migraine with aura through mendelian randomization study

Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-74754-1. Article type: Research Article Keywords: Cannabis use disorder,…

September 4, 2024

Cannabidiol ameliorates mitochondrial disease via PPARγ activation in preclinical models

Abstract Mutations in mitochondrial energy-producing genes lead to a heterogeneous group of untreatable disorders known as primary mitochondrial diseases (MD).…

August 12, 2024

Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging

Abstract Synapses are implicated in many neuropsychiatric illnesses. Here, we provide an overview of in vivo techniques to index synaptic…

May 3, 2023

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

Abstract Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting…

March 8, 2021

Cannabidiol induces autophagy via ERK1/2 activation in neural cells

Abstract Autophagy is a lysosomal catabolic process essential to cell homeostasis and is related to the neuroprotection of the central…

September 3, 2020

The p(l)ot thickens: cannabinoid receptors on astroglial mitochondria coordinate animal behaviors by regulating lactate availability for neurons

Keywords: Cellular neuroscience, Diseases of the nervous system, Metabolic disorders Authors: Erik Keimpema, Tibor Harkany, Alán Alpár Affiliations: grid.22937.3d0000 0000…