RXRG as a Novel Biomarker and its Correlation With Immune Infiltration in Thyroid Carcinoma
Abstract Background/Aim: Thyroid carcinoma (THCA) is the most prevalent type of endocrine cancer. Retinoid X Receptor Gamma (RXRG) encodes a…
Diagnostic markers
Defective X-chromosome inactivation and cancer risk in women
Abstract X-chromosome inactivation (XCI) is a fundamental mechanism in placental mammals that compensates for gene dosage differences between sexes. Using…
Pan-cancer analysis of the immunological and oncogenic roles of ATAD2 with verification in papillary thyroid carcinoma
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-024-73274-2. Article type: Research Article Keywords: ATAD2, Pan-cancer, Papillary…
Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies
Abstract Most neurodegenerative diseases lack definitive diagnostic tests, and the identification of easily accessible and reliable biomarkers remains a critical…
A Comprehensive Pan-Cancer Analysis Reveals Cyclin-Dependent Kinase Inhibitor 2A Gene as a Potential Diagnostic and Prognostic Biomarker in Colon Adenocarcinoma
Abstract Introduction Cyclin-dependent kinase inhibitor 2A (CDKN2A) is a suppressor carcinogenic gene that is upregulated across various types of cancer…
Subtypes in addiction and their neurobehavioral profiles across three functional domains
Abstract Rates of return to use in addiction treatment remain high. We argue that the development of improved treatment options…
ANXA10 is a prognostic biomarker and suppressor of hepatocellular carcinoma: a bioinformatics analysis and experimental validation
Abstract Liver hepatocellular carcinoma (LIHC) is one of the main cancers worldwide and has high morbidity and mortality rates. Although…
Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer’s disease, corticobasal degeneration and progressive supranuclear palsy brains
Abstract Recent mechanistic and structural studies have challenged the classical tauopathy classification approach and revealed the complexity and heterogeneity of…
CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
Abstract Despite recent advances in fluid biomarker research in Alzheimer’s disease (AD), there are no fluid biomarkers or imaging tracers…
MiRNA Deregulation Distinguishes Anaplastic Thyroid Carcinoma (ATC) and Supports Upregulation of Oncogene Expression
Abstract Simple Summary: MicroRNAs are essential regulators of gene expression. Their deregulation is associated with a substantial reorganization of the…