Chemometric Optimization of BF3·OEt2‐Mediated Cyclization of Cannabidiol to Rare Δ⁴‐ and Iso‐THC Isomers
Abstract The acid‐catalyzed conversion of cannabidiol (CBD) to tetrahydrocannabinol and iso‐tetrahydrocannabinol derivatives is a well‐established synthetic strategy. However, since the…