Effect of cannabinol, tetrahydrocannabivarin and cannabidiol on voluntary alcohol consumption
Abstract Aims: Previous studies have demonstrated that the endocannabinoid system plays a significant role in the development of alcohol use…
Delta-9-Tetrahydrocannabivarin
Tetrahydrocannabivarin (THCV) Dose Dependently Blocks or Substitutes for Tetrahydrocannabinol (THC) in a Drug Discrimination Task in Rats
Abstract Delta-9-Tetrahydrocannabivarin (THCV), a naturally occurring cannabinoid and structural analog of THC, exhibits a dual pharmacological profile as a CB1…
Phytocannabinoids as Novel SGLT2 Modulators for Renal Glucose Reabsorption in Type 2 Diabetes Management
Abstract Background: Sodium–glucose cotransporter 2 (SGLT2) inhibitors have transformed type 2 diabetes mellitus (T2DM) management by promoting glucosuria, lowering glycated…
The Impact of Major and Minor Phytocannabinoids on the Maintenance and Function of INS-1 β-Cells Under High-Glucose and High-Lipid Conditions
Abstract Type 2 diabetes mellites (T2DM) is the most common form of diabetes and affects a significant portion of the…
Using In Silico Molecular Docking to Explain Differences in Receptor Binding Behavior of HHC and THCV Isomers: Revealing New Binding Modes
Abstract Even slight structural differences between phytocannabinoid isomers are usually enough to cause a change in their biological properties. In…
Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial Cells
Abstract Atherosclerosis is associated with vascular smooth muscle cell proliferation, chronic vascular inflammation, and leukocyte adhesion. In view of the…
Chemical profiling of Cannabis sativa from eleven Tanzanian regions
Abstract The aim of this research was to investigate the chemical profiles of Cannabis sativa from 11 Tanzanian regions using…
Anticancer properties of cannabidiol and Δ9-tetrahydrocannabinol and synergistic effects with gemcitabine and cisplatin in bladder cancer cell lines
Abstract Introduction: With the legalization of cannabis in multiple jurisdictions throughout the world, a larger proportion of the population consumes…
Anti-cancer properties of cannflavin A and potential synergistic effects with gemcitabine, cisplatin, and cannabinoids in bladder cancer
Abstract Introduction: Several studies have shown anti-tumor effects of components present in cannabis in different models. Unfortunately, little is known…
An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models
Abstract Cannabis contains more than 100 phytocannabinoids. Most of these remain poorly characterized, particularly in neurons. We tested a panel…