ITGA3–MET interaction promotes papillary thyroid cancer progression via ERK and PI3K/AKT pathways
Abstract Background: Studies have examined the role of integrin α3 (ITGA3) in papillary thyroid carcinoma (PTC). However, the functional and…
Degenerative Gelenkerkrankungen
Empfehlungen der DGRh-Kommission für Komplementäre Heilverfahren und Ernährung zur Anwendung von ausgewählten Phytotherapeutika und pflanzlichen Präparaten in der Rheumatologie
Abstract Hintergrund: Pflanzliche Präparate und Phytotherapeutika werden für Symptome und Erkrankungen des rheumatischen Formenkreises angeboten und oft intensiv in der…
Structure–Activity Relationship and Functional Evaluation of Cannabinoid Type-1 Receptor
Abstract The type-1 cannabinoid receptor (CB1R) is a potential therapeutic target in several pathological conditions, including neuropsychological disorders and neurodegenerative…
Oleoylethanolamide Modulates BDNF-ERK Signaling and Neurogenesis in the Hippocampi of Rats Exposed to Δ9-THC and Ethanol Binge Drinking During Adolescence
Abstract Oleoylethanolamide is an endogenous NAE that modulates ethanol-seeking behavior and ethanol-induced neuroinflammation. In the present study we further analyze…
CB1 Allosteric Modulator Org27569 Is an Antagonist/Inverse Agonist of ERK1/2 Signaling
Abstract Introduction: Allosteric modulation of cannabinoid type-1 receptors (CB1) is a novel means through which signaling bias may be exerted.…