Interaction of cytochrome P450 3A4 with cannabinoids and the drug darifenacin
Abstract Cytochrome P450 3A4 (CYP3A4) is an important drug-metabolizing enzyme whose substrate binding mechanism remains incompletely understood because of insufficient…
Cytochrome P450
Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review
Abstract The use of cannabinoids has a history spanning thousands of years, and their pharmacological and toxicological properties, particularly those…
Utilization of Cannabidiol in Post-Organ-Transplant Care
Abstract Cannabidiol (CBD) is one of the major phytochemical constituents of cannabis, Cannabis sativa, widely recognized for its therapeutic potential.…
Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids
Abstract Oxysterols and bile acids are interconnected bioactive lipids playing pivotal roles in diverse physiological and pathological processes. For this…
Genome-wide analysis of the Cannabis sativa cytochrome P450 monooxygenase superfamily and uncovering candidate genes for improved herbicide tolerance
Abstract Cannabis sativa is an economically important crop, yet weed management remains a significant challenge due to limited herbicide options.…
Green rush and red warnings: Retrospective chart review of adverse events of interactions between cannabinoids and psychotropic drugs
Abstract Aim: Our objective was to systematically assess the prevalence and clinical features of adverse events related to interactions between…
Drug–Cannabinoid Interactions in Selected Therapeutics for Symptoms Associated with Epilepsy, Autism Spectrum Disorder, Cancer, Multiple Sclerosis, and Pain
Abstract Clinical practice entails a translation of research that assists in the use of scientific data and therapeutic evidence for…
Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes
Abstract Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease with multiple genetic and a variety of environmental risk factors.…
Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
Abstract Cannabidiol (CBD) is a biologically active, non-psychotropic component of Cannabis sativa whose popularity has grown exponentially in recent years.…
In Vitro Interaction of AB-FUBINACA with Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes and Drug Transporters
Abstract AB-FUBINACA, a synthetic indazole carboxamide cannabinoid, has been used worldwide as a new psychoactive substance. Because drug abusers take…