Interaction of cytochrome P450 3A4 with cannabinoids and the drug darifenacin
Abstract Cytochrome P450 3A4 (CYP3A4) is an important drug-metabolizing enzyme whose substrate binding mechanism remains incompletely understood because of insufficient…
CYP3A4
CYP2C9, CYP3A and CYP2C19 metabolize Δ9-tetrahydrocannabinol to multiple metabolites but metabolism is affected by human liver fatty acid binding protein (FABP1)
Abstract Δ9-tetrahydrocannabinol (THC) is the psychoactive constituent of cannabis. It is cleared predominantly via metabolism. Metabolism to 11-OH-THC by cytochrome…
Targeting calcium signaling in cancer therapy
Abstract The intracellular calcium ions (Ca2+) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating…