Development and characterization of a zeolite based drug delivery system: Application to cannabidiol oral delivery
Abstract The growing interest in the therapeutic potential of cannabidiol (CBD) has led to the need for effective and reliable…
cutaneous drug delivery
Cannabidiol-Loaded Solid Lipid Nanoparticles Ameliorate the Inhibition of Proinflammatory Cytokines and Free Radicals in an In Vitro Inflammation-Induced Cell Model
Abstract Cannabidiol (CBD) is a non-psychoactive compound derived from Cannabis sativa. It has demonstrated promising effects in combating inflammation and…
Assessing the Safety and Therapeutic Efficacy of Cannabidiol Lipid Nanoparticles in Alleviating Metabolic and Memory Impairments and Hippocampal Histopathological Changes in Diabetic Parkinson’s Rats
Abstract Diabetic Parkinson’s disease (DP) is a progressive neurodegenerative disease with metabolic syndrome that is increasing worldwide. Emerging research suggests…
In situ Formation of Polymer Microparticles in Bacterial Nanocellulose Using Alternative and Sustainable Solvents to Incorporate Lipophilic Drugs
Abstract Bacterial nanocellulose has been widely investigated in drug delivery, but the incorporation of lipophilic drugs and controlling release kinetics…
Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma
Abstract The limited benefits of immunotherapy against glioblastoma (GBM) is closely related to the paucity of T cells in brain…
Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures
Abstract Cannabidiol (CBD) has gained attention as a therapeutic agent and is purported to have immunomodulatory, neuroprotective, and anti-seizure effects.…
Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol
Abstract Lipid nanoparticles are currently used to deliver drugs to specific sites in the body, known as targeted therapy. Conjugates…
Receptor-targeted nanoparticles modulate cannabinoid anticancer activity through delayed cell internalization
Abstract Δ9-tetrahydrocannabinol (Δ9-THC) is known for its antitumor activity and palliative effects. However, its unfavorable physicochemical and biopharmaceutical properties, including…
Pharmacokinetics and central accumulation of delta-9-tetrahydrocannabinol (THC) and its bioactive metabolites are influenced by route of administration and sex in rats
Abstract Up to a third of North Americans report using cannabis in the prior month, most commonly through inhalation. Animal…
Polysaccharide Cryogels Containing β-Cyclodextrin for the Delivery of Cannabidiol
Abstract Cannabidiol (CBD) has attracted increasing interest due to its therapeutic potential for treating numerous diseases. However, CBD is very…