Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action
Abstract Our skin safeguards the body homeostasis for health and also provides psychological consolation in social life. Natural essential oils…
Cryoelectron microscopy
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
Abstract The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest of pharmacological…
Cannabidiol inhibits Nav channels through two distinct binding sites
Abstract Cannabidiol (CBD), a major non-psychoactive phytocannabinoid in cannabis, is an effective treatment for some forms of epilepsy and pain.…
Structural basis for activation of CB1 by an endocannabinoid analog
Abstract Endocannabinoids (eCBs) are endogenous ligands of the cannabinoid receptor 1 (CB1), a G protein-coupled receptor that regulates a number…
Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
Abstract TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with…
Structural insights into TRPV2 activation by small molecules
Abstract Transient receptor potential vanilloid 2 (TRPV2) is involved in many critical physiological and pathophysiological processes, making it a promising…
Visualising Silicon in Plants: Histochemistry, Silica Sculptures and Elemental Imaging
Abstract Silicon is a non-essential element for plants and is available in biota as silicic acid. Its presence has been…