Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action
Abstract Our skin safeguards the body homeostasis for health and also provides psychological consolation in social life. Natural essential oils…
Cryoelectron microscopy
The biosynthesis of the odorant 2-methylisoborneol is compartmentalized inside a protein shell
Abstract Terpenoids are the largest class of natural products, found across all domains of life. One of the most abundant…
Structural insights into human ABCD3-mediated peroxisomal acyl-CoA translocation
Abstract Human ABC transporters ABCD1–3 are all localized on the peroxisomal membrane and participate in the β-oxidation of fatty acyl-CoAs,…
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
Abstract The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest of pharmacological…
Cannabidiol inhibits Nav channels through two distinct binding sites
Abstract Cannabidiol (CBD), a major non-psychoactive phytocannabinoid in cannabis, is an effective treatment for some forms of epilepsy and pain.…
Structural basis for activation of CB1 by an endocannabinoid analog
Abstract Endocannabinoids (eCBs) are endogenous ligands of the cannabinoid receptor 1 (CB1), a G protein-coupled receptor that regulates a number…
Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
Abstract TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with…
Molecular basis for polysaccharide recognition and modulated ATP hydrolysis by the O antigen ABC transporter
Abstract O antigens are ubiquitous protective extensions of lipopolysaccharides in the extracellular leaflet of the Gram-negative outer membrane. Following biosynthesis…
Structural basis of sodium-dependent bile salt uptake into the liver
Abstract The liver takes up bile salts from blood to generate bile, enabling absorption of lipophilic nutrients and excretion of…
Structural insights into TRPV2 activation by small molecules
Abstract Transient receptor potential vanilloid 2 (TRPV2) is involved in many critical physiological and pathophysiological processes, making it a promising…