Forty sites of TRP channel regulation
Abstract Transient receptor potential (TRP) channels are polymodal molecular sensors that integrate chemical, thermal, mechanical and electrical stimuli and convert…
cryo-EM
Molecular pharmacology of the onco-TRP channel TRPV6
Abstract TRPV6, a representative of the vanilloid subfamily of TRP channels, serves as the principal calcium uptake channel in the…
Structural mapping techniques distinguish the surfaces of fibrillar 1N3R and 1N4R human tau
Abstract The rigid core of intracellular tau filaments from Alzheimer’s disease (AD), Pick’s disease (PiD), and Corticobasal disease (CBD) brains…
Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
Abstract The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is…
Molecular mechanism of TRPV2 channel modulation by cannabidiol
Abstract Transient receptor potential vanilloid 2 (TRPV2) plays a critical role in neuronal development, cardiac function, immunity, and cancer. Cannabidiol…