Treating Epilepsy with Natural Products: Nonsense or Possibility?
Abstract Epilepsy is a neurological disease characterized by recurrent seizures that can lead to uncontrollable muscle twitching, changes in sensitivity…
cost-effective natural products
Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[d]imidazole-Based Cannabinoid Type 2 (CB2) Receptor Agonists
Abstract The endocannabinoid system (ECS) constitutes a broad-spectrum modulator of homeostasis in mammals, providing therapeutic opportunities for several pathologies. Its…
Using a global diversity panel of Cannabis sativa L. to develop a near InfraRed-based chemometric application for cannabinoid quantification
Abstract C. sativa has gained renewed interest as a cash crop for food, fibre and medicinal markets. Irrespective of the…
Small molecules to perform big roles: The search for Parkinson’s and Huntington’s disease therapeutics
Abstract Neurological motor disorders (NMDs) such as Parkinson’s disease and Huntington’s disease are characterized by the accumulation and aggregation of…
Characterizing the degradation of cannabidiol in an e-liquid formulation
Abstract The reported characteristics of cannabidiol (CBD) have encouraged significant growth in commercial CBD products. There is limited information on…
Xanthohumol microbiome and signature in adults with Crohn’s disease (the XMaS trial): a protocol for a phase II triple-masked, placebo-controlled clinical trial
Abstract Background: Xanthohumol (XN), a bioactive flavonoid from Humulus lupulus with anti-inflammatory properties, has potential benefits for patients with Crohn’s…
A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination
Abstract Eukaryotic cells use G-protein coupled receptors to sense diverse signals, ranging from chemical compounds to light. Here, we exploit…
Potential natural products for the management of autism spectrum disorder
Abstract Autism in a broader sense is a neurodevelopmental disorder, which frequently occurs during early childhood and can last for…
Targeting natural products against SARS-CoV-2
Abstract The human coronavirus disease (COVID-19) pandemic is caused by a novel coronavirus; the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2).…
Will Cannabigerol Trigger Neuroregeneration after a Spinal Cord Injury? An In Vitro Answer from NSC-34 Scratch-Injured Cells Transcriptome
Abstract Spinal cord injury affects the lives of millions of people around the world, often causing disability and, in unfortunate…