Pharmacological mechanism of natural antidepressants: the role of epigenetic modifications
Abstract MDD is a complex mental illness shaped by the interplay between genetic vulnerability and environmental triggers. Its underlying pathophysiological…
cortical spreading depression
Cognitive and neuropsychiatric profiles distinguish atypical parkinsonian syndromes
Abstract Atypical parkinsonian syndromes are distinguished from Parkinson’s disease (PD) by additional neurological signs and characteristic underlying neuropathology. However, they…
Interactions of antidepressants with concomitant medications—safety of complex therapies in multimorbidities
Abstract Depression is the fourth most serious disease in the world. Left untreated, it is a cause of suicide attempts,…
The anti-depression effect and potential mechanism of the petroleum ether fraction of CDB: Integrated network pharmacology and metabolomics
Abstract The combination of Chaidangbo (CDB) is an antidepressant traditional Chinese medicine (TCM) prescription simplified by Xiaoyaosan (a classic antidepressant…
Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics
Abstract The individual and global burden of migraine is of such significance that there are accelerated efforts to develop new…
Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression
Abstract Background: The comorbidity between diabetes mellitus and depression was revealed, and diabetes mellitus increased the prevalence of depressive disorder,…
The neuroprotective effect of traditional Chinese medicinal plants—A critical review
Abstract Neurodegenerative and neuropsychiatric diseases are increasingly affecting individuals’ quality of life, thus increasing their cost to social and health…
Periodontal and peri-implant status and whole salivary interleukin 1-beta levels among individuals using selective serotonin reuptake inhibitors: an observational study
Abstract Objective: Selective serotonin reuptake inhibitors (SSRI) are commonly used for managing psychological diseases such as depression. These disorders are…
Cortisol, Depression, and Anxiety Levels Before and After Short-Term Intensive Nutritional Stabilization in Patients With Severe Anorexia Nervosa
Abstract Introduction: Depression and anxiety are well-known comorbid conditions in patients with anorexia nervosa (AN). Hypercortisolemia in patients with AN…
The antidepressant and anxiolytic effects of cannabinoids in chronic unpredictable stress: a preclinical systematic review and meta-analysis
Abstract Neuroscience research presents contradictory evidence in support of both the protective and destructive effects of cannabinoids in depression. Therefore,…