A cross-cohort computational framework to trace tumor tissue-of-origin based on RNA sequencing
Abstract Carcinoma of unknown primary (CUP) is a type of metastatic cancer with tissue-of-origin (TOO) unidentifiable by traditional methods. CUP…
Computational biology and bioinformatics
HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth
Abstract 3-Hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) is the rate-limiting enzyme for ketone body synthesis, and most current studies focus on mitochondrial…
Comprehensive analysis of PILRΑ’s association with the prognosis, tumor immune infiltration, and immunotherapy in pan-cancer
Abstract Paired immunoglobulin-like type 2 receptor alpha (PILRA) plays a vital role in regulating broad immune responses. However, the roles…
A pan-cancer analysis of lipid metabolic alterations in primary and metastatic cancers
Abstract Metabolic reprogramming is a hallmark of cancers, but pan-cancer level roles of lipid metabolism in cancer development are remains…
Pan-cancer structurome reveals overrepresentation of beta sandwiches and underrepresentation of alpha helical domains
Abstract The recent progress in the prediction of protein structures marked a historical milestone. AlphaFold predicted 200 million protein models…
Pan-cancer analysis of whole-genome doubling and its association with patient prognosis
Abstract Background: Whole-genome doubling (WGD) is a common mutation in cancer. Various studies have suggested that WGD is associated with…
Cancer genomes tolerate deleterious coding mutations through somatic copy number amplifications of wild-type regions
Abstract Cancers evolve under the accumulation of thousands of somatic mutations and chromosomal aberrations. While most coding mutations are deleterious,…
High expression of RNF31 is associated with tumor immune cell infiltration and leads to poor prognosis in liver hepatocellular carcinoma
Abstract Ring finger protein 31 (RNF31) has been found to play an important role in tumor immunity. However, the role…
Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer
Abstract Papillary carcinomas account for the largest proportion of thyroid cancers, with papillary thyroid carcinoma (PTC) being prone to early…
A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance
Abstract Disk-like domain receptor 1 (DDR1) is a crucial regulator of pro-inflammatory mediators and matrix-degrading enzymes. Although mounting evidence supports…