Spindle component 25 predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis
Abstract Spindle component 25 (SPC25) is one of the four proteins that make up the nuclear division cycle 80 (NDC80)…
Computational biology and bioinformatics
Novel T cell exhaustion gene signature to predict prognosis and immunotherapy response in thyroid carcinoma from integrated RNA-sequencing analysis
Abstract Exhausted CD8+ T lymphocytes and tumor-associated macrophages play critical roles in determining cancer prognosis and the efficacy of immunotherapy.…
Long non-coding RNA LINC-PINT as a novel prognostic biomarker in human cancer: a meta-analysis and machine learning
Abstract Long intergenic non-protein coding RNA, P53 induced transcript (LINC-PINT) exhibits different expression patterns in the majority of tumors, yet…
CDK12 is a potential biomarker for diagnosis, prognosis and immunomodulation in pan-cancer
Abstract Cell cycle-dependent protein kinase 12 (CDK12) plays a key role in a variety of carcinogenesis processes and represents a…
Multi-omics pan-cancer analyses identify MCM4 as a promising prognostic and diagnostic biomarker
Abstract Minichromosome Maintenance Complex Component 4 (MCM4) is a vital component of the mini-chromosome maintenance complex family, crucial for initiating…
Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation
Abstract To test the hypothesis that genetic and pharmacological modulation of the classical cannabinoid type 1 (CB1) and 2 (CB2)…
Pan-cancer integrated analysis of ANKRD1 expression, prognostic value, and potential implications in cancer
Abstract There is substantial evidence demonstrating the crucial role of inflammation in oncogenesis. ANKRD1 has been identified as an anti-inflammatory…
Bioinformatics analysis for the identification of Sprouty-related EVH1 domain-containing protein 3 expression and its clinical significance in thyroid carcinoma
Abstract The poorly differentiated thyroid carcinoma (THCA) subtype is associated with an aggressive disease course, a less favorable overall prognosis,…
Prognostic value of mitochondrial CKMT2 in Pan-cancer and its tumor immune correlation analysis
Abstract Mitochondrial metabolism has been shown to play a key role in immune cell survival and function, but mitochondrial creatine…
Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold
Abstract TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and…