Multi-Omics Approaches to Study Molecular Mechanisms in Cannabis sativa
Abstract Cannabis (Cannabis sativa L.), also known as hemp, is one of the oldest cultivated crops, grown for both its…
combined multi-omics analysis
Oncogenic signaling pathway dysregulation landscape reveals the role of pathways at multiple omics levels in pan-cancer
Abstract Dysregulation of signaling pathways plays an essential role in cancer. However, there is not a comprehensive understanding on how…
The role of toll-like receptors (TLRs) in pan-cancer
Abstract Background: Toll-like receptors (TLRs) are important components of the innate and adaptive immune systems, and abnormal TLR expression has…
Comprehensive Analysis of the Expression and Prognosis for MCM4 in Uterine Corpus Endometrial Carcinoma
Abstract Background: Mini chromosome maintenance protein 4 (MCM4) belongs to the family of mini chromosome maintenance proteins (MCMs) that plays…
Single-Cell RNA Sequencing Revealed a 3-Gene Panel Predicted the Diagnosis and Prognosis of Thyroid Papillary Carcinoma and Associated With Tumor Immune Microenvironment
Abstract Objective: The objective of this research was to screen prognostic related genes of thyroid papillary carcinoma (PTC) by single-cell…
Identifying individualized risk subpathways reveals pan-cancer molecular classification based on multi-omics data
Keywords: Individualized risk subpathway, Pathway analysis, Multi-omics, Pan-cancer Authors: Yanjun Xu, Jingwen Wang, Feng Li, Chunlong Zhang, Xuan Zheng, Yang…
Pan-Cancer Integrated Analysis of HSF2 Expression, Prognostic Value and Potential Implications for Cancer Immunity
Abstract Heat shock factor 2 (HSF2), a transcription factor, plays significant roles in corticogenesis and spermatogenesis by regulating various target…
Pan-Cancer DNA Methylation Analysis and Tumor Origin Identification of Carcinoma of Unknown Primary Site Based on Multi-Omics
Abstract The metastatic cancer of unknown primary (CUP) sites remains a leading cause of cancer death with few therapeutic options.…
Pan-Cancer Analysis Reveals the Signature of TMC Family of Genes as a Promising Biomarker for Prognosis and Immunotherapeutic Response
Abstract Transmembrane Channel-like (TMC) genes are critical in the carcinogenesis, proliferation, and cell cycle of human cancers. However, the multi-omics…
Multi-Omics Analysis of the Anti-tumor Synergistic Mechanism and Potential Application of Immune Checkpoint Blockade Combined With Lenvatinib
Abstract The combination of immune-checkpoint blockade (ICB) and lenvatinib has demonstrated robust clinical effects that are superior to those of…