A Multi-Omics Analysis of a Mitophagy-Related Signature in Pan-Cancer
Abstract Mitophagy, an essential process within cellular autophagy, has a critical role in regulating key cellular functions such as reproduction,…
combined multi-omics analysis
iSubGen generates integrative disease subtypes by pairwise similarity assessment
Abstract There are myriad types of biomedical data—molecular, clinical images, and others. When a group of patients with the same…
Novel multi-omics deconfounding variational autoencoders can obtain meaningful disease subtyping
Abstract Unsupervised learning, particularly clustering, plays a pivotal role in disease subtyping and patient stratification, especially with the abundance of…
SexAnnoDB, a knowledgebase of sex-specific regulations from multi-omics data of human cancers
Abstract Background: Sexual differences across molecular levels profoundly impact cancer biology and outcomes. Patient gender significantly influences drug responses, with…
Bioinformatics analysis of ERCC family in pan-cancer and ERCC2 in bladder cancer
Abstract Background: Single nucleotide polymorphisms (SNPs) in DNA repair genes can impair protein function and hinder DNA repair, leading to…
Multi-omics pan-cancer analysis reveals the prognostic values and immunological functions of PPA2, with a spotlight on breast cancer
Abstract Background: Recently, the role of inorganic pyrophosphatase 2 (PPA2) has been remaining merely superficial in many tumors. Hence, the…
Revolutionary multi-omics analysis revealing prognostic signature of thyroid cancer and subsequent in vitro validation of SNAI1 in mediating thyroid cancer progression through EMT
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10238-024-01387-z. Article type: Research Article Keywords: Multi-omics analysis, Thyroid…
Multi-omics pan-cancer study of SPTBN2 and its value as a potential therapeutic target in pancreatic cancer
Abstract SPTBN2 is a protein-coding gene that is closely related to the development of malignant tumors. However, its prognostic value…
Multi-omics pan-cancer analyses identify MCM4 as a promising prognostic and diagnostic biomarker
Abstract Minichromosome Maintenance Complex Component 4 (MCM4) is a vital component of the mini-chromosome maintenance complex family, crucial for initiating…
A pan-cancer multi-omics analysis of lactylation genes associated with tumor microenvironment and cancer development
Abstract Background: Lactylation is a significant post-translational modification bridging the gap between cancer epigenetics and metabolic reprogramming. However, the association…