Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis
Abstract Background: Colorectal cancer (CRC) is one of the most common malignancies in the world. This study proposes to reveal…
colorectal cancer
Antitumor Effects of Cannabis sativa Bioactive Compounds on Colorectal Carcinogenesis
Abstract Cannabis sativa is a multipurpose plant that has been used in medicine for centuries. Recently, considerable research has focused…
Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer
Abstract Colorectal tumors often create an immunosuppressive microenvironment that prevents them from responding to immunotherapy. Cannabidiol (CBD) is a non-psychoactive…
Single-cell analysis of multiple cancer types reveals differences in endothelial cells between tumors and normal tissues
Abstract Endothelial cells (ECs) play an important role in tumor progression. Currently, the main target of anti-angiogenic therapy is the…
Efficient Synthesis for Altering Side Chain Length on Cannabinoid Molecules and Their Effects in Chemotherapy and Chemotherapeutic Induced Neuropathic Pain
Abstract (1) Background: Recently, a number of side chain length variants for tetrahydrocannabinol and cannabidiol have been identified in cannabis;…
Natural essential oils as a new therapeutic tool in colorectal cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12935-022-02806-5. Article type: Review Article Keywords: Colorectal cancer, Natural…
NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet
Abstract Nudix hydrolase 7 (NUDT7) is an enzyme that hydrolyzes CoA species, is highly expressed in the liver, and resides…
ACY1 Downregulation Enhances the Radiosensitivity of Cetuximab-Resistant Colorectal Cancer by Inactivating the Wnt/β-Catenin Signaling Pathway
Abstract Simple Summary: Cetuximab, which can be used in combination with other chemotherapies, is widely used as a standard of…
Tumor microenvironment-related gene selenium-binding protein 1 (SELENBP1) is associated with immunotherapy efficacy and survival in colorectal cancer
Abstract Background: Selenium-binding protein 1 (SELENBP1), a member of the selenium-containing protein family, plays an important role in malignant tumorigenesis…
Oncogenic Role of HMGB1 as An Alarming in Robust Prediction of Immunotherapy Response in Colorectal Cancer
Abstract Simple Summary: The high mobility group box1 (HMGB1) protein operates as an alarm for danger. We explore the correlation…