A decision-space model explains context-specific decision-making
Abstract Optimal decision-making requires consideration of internal and external contexts. Biased decision-making is a transdiagnostic symptom of neuropsychiatric disorders. We…
cognitive vs. motivational component
Beyond Borders: A Longitudinal Study of Nepali Nurses’ Dreams, Realities, and the Pursuit of a Global Career
Abstract The global migration of nurses, particularly from developing nations like Nepal, is a complex tapestry woven with threads of…
Neural basis of adolescent THC-induced potentiation of opioid responses later in life
Abstract Use of one addictive drug typically influences the behavioral response to other drugs, either administered at the same time…
Mobilization of endocannabinoids by midbrain dopamine neurons is required for the encoding of reward prediction
Abstract Brain levels of the endocannabinoid 2-arachidonoylglycerol (2-AG) shape motivated behavior and nucleus accumbens (NAc) dopamine release. However, it is…
Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats
Abstract Rationale: The endocannabinoid system makes critical contributions to reward processing, motivation, and behavioral control. Repeated exposure to THC or…
Changes in striatal dopamine release, sleep, and behavior during spontaneous Δ-9-tetrahydrocannabinol abstinence in male and female mice
Abstract Withdrawal symptoms are observed upon cessation of cannabis use in humans. Although animal studies have examined withdrawal symptoms following…
Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women
Abstract Background: The use of cannabis has been clinically associated with decreased motivation to engage in normally rewarding activities. However,…
Theoretical understanding of contextual motivations for sustained adolescent marijuana use in South Africa
Abstract Background: Although various reasons for adolescent marijuana use have extensively been explored, contextual factors that sustain the practice in…
Cannabinoid Modulation of Dopamine Release During Motivation, Periodic Reinforcement, Exploratory Behavior, Habit Formation, and Attention
Abstract Motivational and attentional processes energize action sequences to facilitate evolutionary competition and promote behavioral fitness. Decades of neuropharmacology, electrophysiology…
The Bivalent Rewarding and Aversive properties of Δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal Modulation Mechanisms in Distinct Striatal Sub-Regions
Abstract The primary psychoactive compound in cannabis, Δ9-tetrahydrocannabinol (THC), is capable of producing bivalent rewarding and aversive affective states through…