Cannabidiol Reduces Inflammatory Lung Damage After Meconium Aspiration in Newborn Piglets
Abstract Aim: To assess the effects of cannabidiol (CBD) on lung damage in a piglet model of meconium aspiration syndrome…
clinical and translational research
Indeterminacy of cannabis impairment and ∆9-tetrahydrocannabinol (∆9-THC) levels in blood and breath
Abstract Previous investigators have found no clear relationship between specific blood concentrations of ∆9-tetrahydrocannabinol (∆9-THC) and impairment, and thus no…
Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies
Abstract Cannabinoid co-administration may enable reduced opioid doses for analgesia. This updated systematic review on the opioid-sparing effects of cannabinoids…
Pharmacokinetics and central accumulation of delta-9-tetrahydrocannabinol (THC) and its bioactive metabolites are influenced by route of administration and sex in rats
Abstract Up to a third of North Americans report using cannabis in the prior month, most commonly through inhalation. Animal…
A comprehensive breath test that confirms recent use of inhaled cannabis within the impairment window
Abstract Legalization of cannabis for medicinal and/or recreational use is expanding globally. Although cannabis is being regulated country by country,…
Co-exposure of cannabinoids with amphetamines and biological, behavioural and health outcomes: a scoping review of animal and human studies
Abstract Rationale: The growing prevalence of psychostimulant (including amphetamine) use and associated health harms, with limited treatment options, present a…
Consideration of sex as a biological variable in the translation of pharmacotherapy for stress-associated drug seeking
Abstract Stress is a frequent precipitant of relapse to drug use. Pharmacotherapies targeting a diverse array of neural systems have…
The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype
Abstract Oncogene-induced senescence provides a barrier against malignant transformation. However, it can also promote cancer through the secretion of a…
Human Laboratory Models of Cannabis Use: Applications for Clinical and Translational Psychiatry Research
Abstract Cannabis is increasingly used by individuals with mental health diagnoses and often purported to treat anxiety and various other…
Non-invasive diffuse optical neuromonitoring during cardiopulmonary resuscitation predicts return of spontaneous circulation
Abstract Neurologic injury is a leading cause of morbidity and mortality following pediatric cardiac arrest. In this study, we assess…