TIMELESS deficiency sensitizes thyroid cancer to cisplatin treatment via the DNA damage repair pathway
Abstract DNA damage repair (DDR) pathway was activated in thyroid cancer under cisplatin treatment. TIMELESS, a circadian rhythm gene, was…
Cisplatin resistance
Combination of Cannabidiol with Cisplatin or Paclitaxel Analysis Using the Chou–Talalay Method and Chemo-Sensitization Evaluation in Platinum-Resistant Ovarian Cancer Cells
Abstract Background/Objectives: Cannabidiol (CBD) is known for its anti-cancer properties in preclinical models and is increasingly used alongside conventional chemotherapy…
Lebanese Cannabis sativa L. extract protects from cisplatin-induced nephrotoxicity in mice by inhibiting podocytes apoptosis
Abstract Background: Cisplatin is an anti-cancer drug used to treat a plethora of solid tumors. However, it is associated with…
Cytotoxicity of natural and synthetic cannabinoids and their synergistic antiproliferative effects with cisplatin in human ovarian cancer cells
Abstract Introduction: Cannabinoids are reported to suppress the growth of ovarian cancer cells, but it is unclear whether structural modifications…
Targeting carbohydrate metabolism in colorectal cancer – synergy between DNA-damaging agents, cannabinoids, and intermittent serum starvation
Abstract Chemotherapy is a therapy of choice for many cancers. However, it is often inefficient for long-term patient survival and…
Targeting Colorectal Cancer: Unravelling the Transcriptomic Impact of Cisplatin and High-THC Cannabis Extract
Abstract Cisplatin and other platinum-derived chemotherapy drugs have been used for the treatment of cancer for a long time and…
Chronic Cannabigerol as an Effective Therapeutic for Cisplatin-Induced Neuropathic Pain
Abstract Cannabigerol (CBG), derived from the cannabis plant, acts as an acute analgesic in a model of cisplatin-induced peripheral neuropathy…
Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells
Abstract Platinum-derived chemotherapy medications are often combined with other conventional therapies for treating different tumors, including colorectal cancer. However, the…
Anticancer properties of cannabidiol and Δ9-tetrahydrocannabinol and synergistic effects with gemcitabine and cisplatin in bladder cancer cell lines
Abstract Introduction: With the legalization of cannabis in multiple jurisdictions throughout the world, a larger proportion of the population consumes…
Cannabidiol and Cannabis Sativa as a potential treatment in vitro prostate cancer cells silenced with RBBp6 and PC3 xenograft
Abstract Background: Prostate cancer is the second most frequently occurring carcinoma in males worldwide and one of the leading causes…