Hallmarks of primary headache: part 3 – cluster headache
Abstract Background: Cluster headache (CH) is a rare primary headache disorder characterized by recurrent episodes of strictly unilateral excruciating pain…
Circadian rhythm
TIMELESS deficiency sensitizes thyroid cancer to cisplatin treatment via the DNA damage repair pathway
Abstract DNA damage repair (DDR) pathway was activated in thyroid cancer under cisplatin treatment. TIMELESS, a circadian rhythm gene, was…
Effects of cannabidiol to circadian period, sleep, life span, close-proximity rhythm, egg reproduction and motor function in Drosophila melanogaster
Abstract Cannabidiol (CBD), a non-psychoactive cannabinoid, has been studied for its various health-promoting effects recently. This study investigates the effects…
A Sex-Dependent Cannabinoid CB1 Receptor Role in Circadian Tearing of the Mouse
Abstract Purpose: We have shown that cannabinoid CB1 receptors regulate both salivation and tearing, but for tearing, this regulation is…
Exploring the Prevalence and Patterns of Use of Sleep Aids and Stimulants Among Emergency Physicians and EMS Providers in Saudi Arabia
Abstract Purpose: This study explores the prevalence and patterns of the use of pharmacologic sleep aids and stimulants among Saudi…
Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways
Abstract Neurodegenerative disorders affect fifteen percent of the world’s population and pose a significant financial burden to all nations. Cognitive…
Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex
Abstract The mammalian circadian clock is driven by a transcriptional–translational feedback loop, which produces robust 24-hr rhythms. Proper oscillation of…