Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain
Abstract Chronic pain is a common detrimental condition that affects around 20% of the world population. The current drugs to…
Chronic pain
Cannabinoids in Chronic Non-Cancer Pain: A Systematic Review and Meta-Analysis
Abstract Background: For patients with chronic, non-cancer pain, traditional pain-relieving medications include opioids, which have shown benefits but are associated…
A Review of Scientific Evidence for THC:CBD Oromucosal Spray (Nabiximols) in the Management of Chronic Pain
Abstract The 20% prevalence of chronic pain in the general population is a major health concern given the often profound…
Cannabis and Cannabinoids in the Treatment of Rheumatic Diseases
Abstract Chronic pain is a common complaint among patients, and rheumatic diseases are a common cause for chronic pain. Current…
Medical Cannabis for the Primary Care Physician
Abstract Medical cannabis use is common in the United States and increasingly more socially acceptable. As more patients seek out…
Cannabidiol (CBD) Consumption and Perceived Impact on Extrahepatic Symptoms in Patients with Autoimmune Hepatitis
Abstract Background and Aims: Utilization and safety of cannabidiol (CBD) in patients with autoimmune hepatitis (AIH) are currently unknown. We…
Evaluating the efficacy of cannabidiol to manage surgically induced neuropathic pain in a preclinical rat model: Are T cells a sexually dimorphic target?
Abstract Background: Considering the poorly understood etiology and complex symptoms of chronic neuropathic pain (NP), the lack of effective treatments,…
Safety and Efficacy of Medical Cannabis in Fibromyalgia
Abstract Background: Chronic pain may be treated by medical cannabis. Yet, there is scarce evidence to support the role of…
Efficacy and safety of cannabidiol followed by an open label add-on of tetrahydrocannabinol for the treatment of chronic pain in patients with rheumatoid arthritis or ankylosing spondylitis: protocol for a multicentre, randomised, placebo-controlled study
Abstract Introduction: Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic, systemic, inflammatory diseases, primarily in the musculoskeletal system. Pain…
Tetrahydrocannabinol Reduces Hapten-Driven Mast Cell Accumulation and Persistent Tactile Sensitivity in Mouse Model of Allergen-Provoked Localized Vulvodynia
Abstract Vulvodynia is a remarkably prevalent chronic pain condition of unknown etiology. An increase in numbers of vulvar mast cells…