Dietary targeting of TRPM8 rewires macrophage immunometabolism reducing colitis severity
Abstract The interplay between diet, host genetics, microbiota, and immune system has a key role in the pathogenesis of inflammatory…
Chronic inflammation
Inflammation and cancer: friend or foe?
Abstract Chronic inflammation plays a crucial role in the onset and progression of pathologies like neurodegenerative and cardiovascular diseases, diabetes,…
Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV)
Abstract Background: To evaluate drug use (alcohol, tobacco, cannabis and other drugs) and its association with mean CD4/CD8 T cell…
Inflammation and immune dysfunction in Parkinson disease
Abstract Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral organs as well as the central nervous system…
Epigenetic Regulation of Cannabinoid-Mediated Attenuation of Inflammation and Its Impact on the Use of Cannabinoids to Treat Autoimmune Diseases
Abstract Chronic inflammation is considered to be a silent killer because it is the underlying cause of a wide range…
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
Abstract Interleukin 33 (IL-33) is among the earliest-released cytokines in response to allergens that orchestrate type 2 immunity. The prolyl…
Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants
Abstract Cannabis and analogs of Δ9-tetrahydrocannabinol have been used for therapeutic purposes, but their therapeutic use remains limited because of…