Isoflavonoids and Epigenetic Modulation: Therapeutic Insights for Cancer Treatment
Abstract Isolavonoides represent the second largest subgroup of flavonoids and have an influence on critical molecular pathways and restore cellular…
chemogenetics
Analysis of C9orf72 repeat length in progressive supranuclear palsy, corticobasal syndrome, corticobasal degeneration, and atypical parkinsonism
Abstract Background: Pathogenic hexanucleotide repeat expansions in C9orf72 are the commonest genetic cause of frontotemporal dementia and/or amyotrophic lateral sclerosis.…
Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives
Abstract Obsessive-Compulsive Disorder (OCD), a prevalent neuropsychiatric condition, affects approximately 2%-3% of the global population. This paper provides an extensive…
Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats
Abstract Rationale: Adolescent cannabis use is linked to later-life changes in cognition, learning, and memory. Rodent experimental studies suggest Δ9-tetrahydrocannabinol…
Comprehensive pan-cancer analysis of inflammatory age-clock-related genes as prognostic and immunity markers based on multi-omics data
Abstract Inflammatory age (iAge) is a vital concept for understanding the intricate interplay between chronic inflammation and aging in the…
Neuropathology and emerging biomarkers in corticobasal syndrome
Abstract Corticobasal syndrome (CBS) is a clinical syndrome characterised by progressive asymmetric limb rigidity and apraxia with dystonia, myoclonus, cortical…
Parkinson’s Disease and SARS-CoV-2 Infection: Particularities of Molecular and Cellular Mechanisms Regarding Pathogenesis and Treatment
Abstract Accumulating data suggest that chronic neuroinflammation-mediated neurodegeneration is a significant contributing factor for progressive neuronal and glial cell death…
Are innovation and new technologies in precision medicine paving a new era in patients centric care?
Abstract Healthcare is undergoing a transformation, and it is imperative to leverage new technologies to generate new data and support…