Cannabinoids in Motor Control: From Receptor Distribution to Motor Disorders
Abstract Cannabinoid receptors occupy strategic control nodes within motor circuitry, making them potential targets for modulating different motor manifestations. They…
central spasticity
ABCB1 polymorphisms are associated with clinical response to nabiximols in patients with multiple sclerosis-related spasticity
Keywords: Multiple sclerosis, Single nucleotide polymorphisms, Nabiximols, Spasticity, ABCB1 Authors: Alessandra Gemma, Marco Mauri, Paola Banfi, Maurizio Versino, Alen Zollo,…
Evaluating Vaporized Cannabinoid Therapy in Multiple Sclerosis: Findings from a Prospective Single-Center Clinical Study
Abstract Introduction: Multiple Sclerosis (MS) is associated with a wide range of debilitating symptoms, and conventional therapies often fail to…
Cannabinoids for spasticity in patients with multiple sclerosis: A systematic review and meta-analysis
Abstract Background: One of the most disabling symptoms of patients with multiple sclerosis (MS) is spasticity which affects their quality…
Effectiveness, Safety and Patients’ Satisfaction of Nabiximols (Sativex®) on Multiple Sclerosis Spasticity and Related Symptoms in a Swiss Multicenter Study
Abstract Background: Cannabinoid oro-mucosal spray nabiximols is approved for patients with moderate to severe multiple sclerosis spasticity (MSS) resistant to…
Trends in prescription and cost of Sativex, a cannabinoid-based medicine, in treating patients with multiple sclerosis in England
Abstract Aim: Cannabis-based medication has recently been made available in the NHS for reducing pain and spasticity in patients with…
A post hoc evaluation of the shift in spasticity category in individuals with multiple sclerosis-related spasticity treated with nabiximols
Abstract Background: Over 80% of individuals with multiple sclerosis (MS) experience MS-associated spasticity (MSS). In many European countries, after failure…
Cannabis-Based Medicine for Neuropathic Pain and Spasticity—A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial
Abstract Patients with multiple sclerosis (MS) and spinal cord injury (SCI) commonly sustain central neuropathic pain (NP) and spasticity. Despite…
Change in upper limb function in people with multiple sclerosis treated with nabiximols: a quantitative kinematic pilot study
Abstract Objectives: Nabiximols represents an increasingly employed add-on treatment option for spasticity in people with multiple sclerosis (PwMS) who either…
Theoretical and Therapeutic Implications of the Spasticity-Plus Syndrome Model in Multiple Sclerosis
Abstract In patients with multiple sclerosis (MS), a typical pattern of muscle tone alteration, known as spasticity, is frequently observed…