Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
Abstract The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids…
central nervous system
Exploring Cannabidiol’s Role in Regenerative Medicine: Focus on Neural and Skeletal Tissues
Abstract Cannabidiol (CBD) is a non-psychotropic compound found in plants of the Cannabis genus, extensively studied for its therapeutic potential.…
Dysregulation of the endocannabinoid system – a key factor in the progression of multiple sclerosis?
Abstract The endocannabinoid system has been implicated in the pathophysiology of multiple sclerosis (MS), yet its role across different disease…
Cannabis use, oral dysbiosis, and neurological disorders
Abstract Cannabis (marijuana) is a leafy plant that has medical, recreational, and other uses. Cannabis is socially accepted and widely…
Biobehavioral Interactions between Endocannabinoid and Hypothalamic-pituitary-adrenal Systems in Psychosis: A Systematic Review
Abstract Background: The diathesis-stress paradigm and the cannabinoid-hypothesis have been proposed as possible pathophysiological models of schizophrenia. However, they have…
Cannabinoids and Multiple Sclerosis: A Critical Analysis of Therapeutic Potentials and Safety Concerns
Abstract Multiple sclerosis (MS) is a complicated condition in which the immune system attacks myelinated axons in the central nervous…
Drug reprofiling history and potential therapies against Parkinson’s disease
Abstract Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing “old”…
Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis
Abstract The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal barrier function and immune regulation are key determinants…
Prolonged efavirenz exposure reduces peripheral oxytocin and vasopressin comparable to known drugs of addiction in male Sprague Dawley rats
Abstract Introduction: Several drugs of abuse (DOA) are capable of modulating neurohypophysial hormones, such as oxytocin (OT) and vasopressin (VP),…
Anandamide Influences Interleukin-1β Synthesis and IL-1 System Gene Expressions in the Ovine Hypothalamus during Endo-Toxin-Induced Inflammation
Abstract Simple Summary: Pro-inflammatory cytokines are considered to be one of the most important mediators affecting the function of central…