The tumor suppressor role and ceRNA network of miR-1294 in cancer
Abstract miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated…
cell signaling pathways
A pan-cancer analysis of the oncogenic role of procollagen C-endopeptidase enhancer (PCOLCE) in human
Abstract There is no evidence showing that the expression of procollagen C-endopeptidase enhancer (PCOLCE) is associated with human tumors, and…
The Structure, Function and Regulation of Protein Tyrosine Phosphatase Receptor Type J and Its Role in Diseases
Abstract Protein tyrosine phosphatase receptor type J (PTPRJ), also known as DEP-1, HPTPη, or CD148, belongs to the R3 subfamily…
LPCAT1 acts as an independent prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma
Abstract Background: Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is overexpressed in multiple human tumors. However, the role of LPCAT1 in hepatocellular carcinoma…
Aberrant expression of microRNA-4443 (miR-4443) in human diseases
Abstract miRNA is a small endogenous RNA and an important regulator of gene expression. miR-4443 is abnormally expressed in 12…
Oncogenic signaling pathway dysregulation landscape reveals the role of pathways at multiple omics levels in pan-cancer
Abstract Dysregulation of signaling pathways plays an essential role in cancer. However, there is not a comprehensive understanding on how…
Therapeutic Potential of Cannabinoids on Tumor Microenvironment: A Molecular Switch in Neoplasia Transformation
Abstract The efficacy of chemotherapy depends on the tumor microenvironment. This microenvironment consists of a complex cellular network that can…
Multiomics analysis of tumor mutational burden across cancer types
Keywords: Tumor mutational burden (TMB), Molecular alterations, Differential expression, Signaling pathway, Immunology, Survival Authors: Lin Li, Long Bai, Huan Lin,…
Neurofibromatosis: Molecular Pathogenesis and Natural Compounds as Potential Treatments
Abstract The neurofibromatosis syndromes, including NF1, NF2, and schwannomatosis, are tumor suppressor syndromes characterized by multiple nervous system tumors, particularly…
Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier
Abstract Recent studies have identified great similarities and interferences between the epithelial layers of the digestive tract, the airways and…