CENPF promotes papillary thyroid cancer progression by mediating cell proliferation and apoptosis
Abstract Papillary thyroid cancer (PTHCA) accounts for ~85% cases of thyroid cancer and exhibits high incidence. Targeted therapy is an…
cell cycle arrest
The pro-apoptosis effects of Echinacea purpurea and Cannabis sativa extracts in human lung cancer cells through caspase-dependent pathway
Abstract Background: Considering the advantages of using medicinal herbs as supplementary treatments to sensitize conventional anti-cancer drugs, studying functional mechanisms…
The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities
Abstract DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In…
Correlation of NUF2 Overexpression with Poorer Patient Survival in Multiple Cancers
Abstract Purpose: NUF2 has been implicated in multiple cancers recently, suggesting NUF2 may play a role in the common tumorigenesis…
Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells
Abstract The main chemical component of cannabis, cannabidiol (CBD), has been shown to have antitumor properties. The present study examined…
Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer
Abstract Aberrations in histone post-translational modifications (PTMs), as well as in the histone modifying enzymes (HMEs) that catalyze their deposition…
Identification of Synergistic Interaction Between Cannabis-Derived Compounds for Cytotoxic Activity in Colorectal Cancer Cell Lines and Colon Polyps That Induces Apoptosis-Related Cell Death and Distinct Gene Expression
Abstract Introduction: Colorectal cancer remains the third most common cancer diagnosis and fourth leading cause of cancer-related mortality worldwide. Purified…
E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle
Abstract Background: Thyroid cancer is the most common malignancy of endocrine system, and papillary thyroid cancer (PTC) is the most…
The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism
Abstract Ki-67 and RepoMan have key roles during mitotic exit. Previously, we showed that Ki-67 organizes the mitotic chromosome periphery…
Inhibitory effects and molecular mechanisms of tetrahydrocurcumin against human breast cancer MCF-7 cells
Abstract Background: Tetrahydrocurcumin (THC), an active metabolite of curcumin, has been reported to have similar biological effects to curcumin, but…