Systematic analysis of the aberrances and functional implications of cuproptosis in cancer
Abstract Cuproptosis is a novel form of cell death driven by a copper-dependent proteotoxic stress response whose comprehensive landscape in…
Cell biology
Experimental and clinical data analysis for identification of COVID-19 resistant ACE2 mutations
Abstract The high magnitude zoonotic event has caused by Severe Acute Respitarory Syndrome CoronaVirus-2 (SARS-CoV-2) is Coronavirus Disease-2019 (COVID-19) epidemics.…
Chronic low-dose Δ9-tetrahydrocannabinol (THC) treatment stabilizes dendritic spines in 18-month-old mice
Abstract Cognitive functions decline during aging. This decline could be caused by changes in dendritic spine stability and altered spine…
Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer
Abstract Intensive research in the field of cancer biology has revealed unique methods of communication between cells through extracellular vesicles…
Systematic analysis of expression profiles and prognostic significance for MMDS-related iron–sulfur proteins in renal clear cell carcinoma
Abstract Mitochondrial metabolism disorders play an important role in the occurrence and development of tumors, and iron–sulfur protein is an…
A fluorescence recovery after photobleaching protocol to measure surface diffusion of DAGLα in primary cultured cortical mouse neurons
Abstract This protocol describes using fluorescence recovery after photobleaching (FRAP) of a superecliptic pHluorin (SEP)-diacylglycerol lipase α (DAGLα) to measure…
Comparative assessment of antimicrobial, antiradical and cytotoxic activities of cannabidiol and its propyl analogue cannabidivarin
Abstract Cannabidiol and cannabidivarin are phytocannabinoids produced by Cannabis indica and Cannabis sativa. Cannabidiol has been studied more extensively than…
Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development
Abstract Ongoing societal changes in views on the medical and recreational roles of cannabis increased the use of concentrated plant…
The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity
Abstract Dynamic interactions of proteins with lipid membranes are essential regulatory events in biology, but remain rudimentarily understood and particularly…
The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition
Abstract One largely unknown question in cell biology is the discrimination between inconsequential and functional transcriptional events with relevant regulatory…