Derivation of a health‐based guidance value for Δ8 ‐tetrahydrocannabinol (Δ8 ‐THC) and its occurrence in food
Abstract The European Food Safety Authority (EFSA) was asked to deliver a scientific opinion on the derivation of a health‐based…
cardiotoxicity
Acute toxicological evaluation of bone-targeted parathyroid hormone-related peptide (PTHrP) antagonist to inhibit breast cancer metastases to bone
Abstract The present study evaluates the in vivo acute toxicological profile and drug distribution of a novel bone-targeted parathyroid hormone-related…
Investigation of Cannabidiol’s Protective Effects on Cadmium‐Induced Toxicity in Mice
Abstract Current chelation treatments used for cadmium poisoning may cause some serious side effects. Thus, safer novel treatments could be…
Improved Therapeutic Efficacy of Doxorubicin Chemotherapy With Cannabidiol in 4T1 Mice Breast Cancer Model
Abstract Background: High dose chemotherapy is one of the therapeutic strategies for breast cancer and doxorubicin (DOX) as a chemotherapy…
Brugada Phenotype Following a Cocaine Overdose
Abstract Brugada syndrome is a rare cardiac condition characterized by distinctive electrocardiogram patterns, predisposing individuals to fatal arrhythmias. While primarily…
Polyphenol-rich fermented hempseed ethanol extracts improve obesity, oxidative stress, and neural health in high-glucose diet-induced Caenorhabditis elegans
Abstract Fermented hempseeds demonstrated superior anti-obesity and antioxidant capabilities. The inhibition capacity of AChE was higher in fermented hempseeds. Phenolic…
The synthetic cannabinoids menace: a review of health risks and toxicity
Abstract Graphical Abstract: Article type: Review Article Keywords: Synthetic cannabinoids, Spices, Designer drugs, Toxicity Authors: Ayman Alzu’bi ⚬, Fatimah Almahasneh,…
Update on Cannabidiol Clinical Toxicity and Adverse Effects: A Systematic Review
Abstract Background: Compelling evidence from preclinical and clinical studies supports the therapeutic role of cannabidiol (CBD) in several medical disorders.…
An Individuality of Response to Cannabinoids: Challenges in Safety and Efficacy of Cannabis Products
Abstract Since legalization, cannabis/marijuana has been gaining considerable attention as a functional ingredient in food. ∆-9 tetrahydrocannabinol (THC), cannabidiol (CBD),…
Off-target pharmacological profiling of synthetic cannabinoid receptor agonists including AMB-FUBINACA, CUMYL-PINACA, PB-22, and XLR-11
Abstract Introduction: Synthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive substances that have been associated with…