Dysregulation of the endocannabinoid system – a key factor in the progression of multiple sclerosis?
Abstract The endocannabinoid system has been implicated in the pathophysiology of multiple sclerosis (MS), yet its role across different disease…
Cannabinoid Receptor Type 1
Endocannabinoid System Receptors at the Hip and Stifle Joints of Middle-Aged Dogs: A Novel Target for the Therapeutic Use of Cannabis sativa Extract in Canine Arthropathies
Abstract Simple Summary: The endocannabinoid system (ECS) plays a crucial role in various processes in animals, including pain, inflammation, and…
Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription
Abstract Interaction of cannabinoid receptor type 1 (CB1) and GABAergic neuronal activity is involved in drug abuse-related behavior. However, its…
Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder
Abstract Post-Traumatic Stress Disorder (PTSD), characterized by re-experiencing, avoidance, negative affect, and impaired memory processing, may develop after traumatic events.…
Cannabinoid Receptor 1 Inhibition in Chronic Kidney Disease: A New Therapeutic Toolbox
Abstract Chronic kidney disease (CKD) concerns millions of individuals worldwide, with few therapeutic strategies available to date. Recent evidence suggests…
Allosteric Modulation of Cannabinoid Receptor 1—Current Challenges and Future Opportunities
Abstract The cannabinoid receptor type 1 (CB1R), a G protein-coupled receptor (GPCR), plays an essential role in the control of…
Endocannabinoids in the Gut
Abstract Cannabis has been used medicinally for centuries to treat a variety of disorders, including those associated with the gastrointestinal…
Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism
Abstract ► Ghrelin requires GHS-R1a for its effect on hypothalamic, liver and adipose tissue AMPK activity. ► An intact ghrelin…